Intrauterine Insemination has got a success rate of not more than 15% per cycle and so one should not lose hope, if the first cycle has not worked. In fact they must consult the doctor again. The doctor will decide as to how many many cycles of IUI can be performed for a particular couple. Yes, ofcourse, after having tried 3 to 4 IUI cycles, without any demonstrable problem in the couple, it is not wise to try more and more IUI cycles, especially if the age of the woman is more than33 or 34, it is wiser to look at options that can give a better chances for pregnancy, options like IVF