An review of the definitions, presentation, and management of sepsis and septic shock, including fluid and pressor recommendations. Useful additional resources: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3): https://jamanetwork.com/journals/jama/fullarticle/2492881 Strong Medicine video on fluid resuscitation: https://www.youtube.com/watch?v=r14sqgk2d0Q&list=PLYojB5NEEakWOfKcCcCZBMlKIJLofiOhp&index=3 Strong Medicine video on pressors: https://www.youtube.com/watch?v=WHGURz11-nE An alternative (but compelling) theory on lactic acid production in shock: https://ccforum.biomedcentral.com/articles/10.1186/s13054-014-0503-3 Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: https://www.ncbi.nlm.nih.gov/pubmed/27940189 (be aware that there is criticism of this protocol, which has not been replicated in an RCT)