A CryoEM approach allows Wisedchaisri et al. to describe how a voltage-gated sodium channel transitions from the resting to activated (open) state. Check out the paper at: https://www.cell.com/cell/fulltext/S0092-8674(19)30734-2 Wisedchaisri, G., Tonggu, L., McCord, E., Gamal El-Din, T.M., Wang, L., Zheng, N., and Catterall, W.A. (2019). Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel. Cell. 178. For the best of Cell Press Videos, visit www.cell.com/video