The best antidepressant for anxiety and depression depends on your previous use or experience of the drug, its effectiveness, side effects and possible interaction with other drugs. Watch the video to see why Sertraline (Zoloft, Lustral) would be my top choice, then Citalopram (Celexa) and Escitalopram (Lexapro). Mirtazapine is the alternative first choice if sleep is a main problem with depression and anxiety but can only be taken at night and has side effects such as weight gain. #mentalhealth #depression #anxiety